Calculate mean pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR), transpulmonary gradient (TPG), and diastolic pressure gradient (DPG) from right heart catheterization data. Includes ESC/ERS 2022 pulmonary hypertension classification.
✓ Verified: ESC/ERS Pulmonary Hypertension Guidelines 2022 — April 2026
Right heart cath systolic PA pressureEnter systolic PAP.
Right heart cath diastolic PA pressureEnter diastolic PAP.
Pulmonary capillary wedge pressure
For PVR calculation (requires PCWP)
Direct measurement overrides calculated value
Mean PAP (mPAP)
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⚠️ Medical Disclaimer: PH diagnosis and classification requires full clinical assessment by a pulmonologist or cardiologist with complete RHC data and clinical context. This calculator is for educational reference only.
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Sources & Methodology
🛡️Formulas and PH classification per ESC/ERS 2022 Pulmonary Hypertension Guidelines (European Heart Journal).
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ESC/ERS 2022 Pulmonary Hypertension Guidelines — European Heart Journal
Mean pulmonary artery pressure (mPAP) is the average pressure in the pulmonary artery throughout the cardiac cycle. Because the pulmonary artery spends approximately two-thirds of each cycle in diastole, mPAP is calculated as: mPAP = diastolic PAP + 1/3 (systolic PAP - diastolic PAP). This is equivalent to (sPAP + 2 x dPAP) / 3.
The ESC/ERS 2022 guidelines updated the definition of pulmonary hypertension from mPAP above 25 mmHg to mPAP above 20 mmHg at rest. This earlier threshold allows identification and treatment of patients at an earlier, more reversible stage of disease.
Hemodynamic Classification of Pulmonary Hypertension (ESC/ERS 2022)
Definition
mPAP
PCWP
PVR
Category
Pre-capillary PH
Above 20
At or below 15
Above 2 WU
Groups 1, 3, 4, 5
Isolated post-capillary PH
Above 20
Above 15
At or below 2 WU
Group 2 (left heart)
Combined pre+post-capillary
Above 20
Above 15
Above 2 WU
Group 2 (mixed)
Normal
At or below 20
At or below 15
At or below 2 WU
No PH
TPG vs DPG — Which to Use?
Both TPG (mPAP - PCWP) and DPG (dPAP - PCWP) identify pre-capillary components in patients with post-capillary PH (left heart disease). DPG is more specific than TPG — it is less affected by elevated PCWP and high pulmonary blood flow. DPG above 7 mmHg with PVR above 2 WU indicates combined pre- and post-capillary PH, which has worse prognosis and may need PAH-specific therapy consideration.
💡 2022 ESC Update — What Changed: The PH threshold dropped from mPAP above 25 to mPAP above 20 mmHg. PVR threshold changed from above 3 WU to above 2 WU for pre-capillary definition. A new borderline range (mPAP 21-24 mmHg) was identified as elevated mean PAP — requiring monitoring even without meeting full PH criteria. Earlier detection enables earlier treatment of reversible disease.
Frequently Asked Questions
mPAP = dPAP + 1/3(sPAP - dPAP). It is the average pulmonary artery pressure throughout the cardiac cycle. Normal mPAP is below 20 mmHg at rest (ESC/ERS 2022).
mPAP above 20 mmHg at rest (updated from previous threshold of 25 mmHg). Pre-capillary PH also requires PVR above 2 Wood units. Earlier threshold allows earlier diagnosis and treatment.
TPG = mPAP - PCWP. Normal below 12 mmHg. TPG above 12 with PVR above 2 WU confirms pre-capillary PH. Important for distinguishing pre- from post-capillary PH in heart failure.
Pulmonary capillary wedge pressure reflects left atrial pressure, measured by wedging a balloon catheter in a pulmonary artery. Normal: 6-12 mmHg. PCWP above 15 mmHg indicates post-capillary cause of PH.
5 WHO/ESC groups: Group 1 (PAH), Group 2 (left heart disease), Group 3 (lung disease), Group 4 (CTEPH), Group 5 (unclear). Hemodynamic categorization into pre- vs post-capillary guides group assignment.
DPG = dPAP - PCWP. Normal below 7 mmHg. DPG above 7 with PVR above 2 WU indicates combined pre- and post-capillary PH in left heart disease. More specific than TPG for identifying true PVD.
Yes. RHC is the gold standard for definitive PH diagnosis. Echo screens for elevated RVSP but cannot provide direct mPAP, PVR, or PCWP needed for definitive diagnosis and treatment decisions.